Loaded Chicken Pesto Panini Recipe
Introduction
This Loaded Chicken Pesto Panini is a flavorful and satisfying sandwich that combines melty cheese, savory chicken, fresh vegetables, and a vibrant homemade pesto. Perfect for an easy dinner or elevated lunch, it’s quick to make and sure to become a new favorite in your meal rotation.

Ingredients
- For the Homemade Basil Pesto:
- 1/4 cup extra virgin olive oil
- 1/3 cup nuts (a mix of walnuts and pine nuts recommended)
- 1/2 tsp sea salt
- Juice of 1 lemon
- 2 handfuls fresh basil leaves
- 1 tbsp nutritional yeast
- 1/2 tsp minced garlic
- 1/4 tsp ground pepper
- 2 tbsp water (optional, for consistency)
- For the Panini:
- 2 slices bread of choice (Organic Rosemary Sourdough is ideal)
- 1 tbsp ghee
- 3 tbsp prepared pesto
- Calabrian peppers (optional, for spice)
- 1/2 avocado, thinly sliced
- 1 jar marinated roasted sweet red peppers
- 2-4 slices cheese (goat cheese recommended)
- 4 artichoke hearts, quartered
- 6 slices organic deli chicken
- 1 cup arugula
- Fresh cracked black pepper
- Sea salt
Instructions
- Step 1: Prepare the basil pesto by combining the olive oil, nuts, sea salt, lemon juice, basil leaves, nutritional yeast, garlic, and ground pepper in a food processor. Pulse until smooth, adding water as needed to reach your desired consistency. Refrigerate any extra pesto in an airtight container for up to 5 days or freeze in an ice cube tray for up to 3 months.
- Step 2: Heat your panini press. Spread ghee generously on the outside of each bread slice to help achieve a crispy golden crust.
- Step 3: On the inside of one bread slice, spread the pesto evenly. Add Calabrian peppers to the other slice if using.
- Step 4: Layer the avocado slices, roasted sweet red peppers, deli chicken, cheese, artichokes, and arugula on one slice of bread. Season with fresh cracked pepper and sea salt to taste.
- Step 5: Close the sandwich with the other piece of bread, ghee side out. Place the sandwich in the heated panini press and toast until the bread is golden and crispy and the cheese has melted, about 5 minutes.
- Step 6: Remove from press carefully, slice if desired, and serve immediately.
Tips & Variations
- If you don’t have a panini press, toast the sandwich in a hot skillet over medium heat for about 2 minutes per side. Cover with a lid to help melt the cheese evenly.
- Feel free to substitute turkey or your favorite deli meat in place of chicken for a different flavor.
- Swap goat cheese for mozzarella or cheddar depending on your preference.
- Adjust spice level by omitting Calabrian peppers if you prefer a milder sandwich.
- Use gluten-free bread if needed to accommodate dietary restrictions, though texture may vary.
Storage
Store any leftover pesto in an airtight container in the refrigerator for up to 5 days or freeze for longer storage. The assembled panini is best enjoyed fresh but can be wrapped and refrigerated for up to 1 day. Reheat in a skillet or panini press to restore crispness and melt the cheese.
How to Serve

Serve this delicious recipe with your favorite sides.
FAQs
Can I make the pesto ahead of time?
Yes! The homemade pesto keeps well in the fridge for up to 5 days and can also be frozen in ice cube trays for up to 3 months. This way, you can quickly assemble your panini whenever you like.
What if I don’t have a panini press?
You can easily make this panini using a hot skillet. Toast the sandwich for about 2 minutes on each side and cover it with a lid to help melt the cheese thoroughly.
PrintLoaded Chicken Pesto Panini Recipe
This Loaded Chicken Pesto Panini is a flavorful and satisfying sandwich featuring creamy dairy-free pesto, spicy Calabrian peppers, fresh avocado, roasted sweet peppers, tender organic deli chicken, goat cheese, artichokes, and peppery arugula layered on toasted rosemary sourdough bread. Crispy and melty thanks to the panini press, it makes a perfect high-protein meal ideal for lunch or dinner, delivering balanced nutrition and bold, fresh flavors.
- Prep Time: 15 minutes
- Cook Time: 5 minutes
- Total Time: 20 minutes
- Yield: 1 panini sandwich 1x
- Category: Sandwich
- Method: Grilling
- Cuisine: American
- Diet: Gluten Free
Ingredients
Homemade Basil Pesto
- 1/4 cup extra virgin olive oil
- 1/3 cup nuts (a mix of walnuts and pine nuts)
- 1/2 tsp sea salt
- 1 lemon, squeezed
- 2 handfuls fresh basil leaves
- 1 tbsp nutritional yeast
- 1/2 tsp minced garlic
- 1/4 tsp ground pepper
- 2 tbsp water
Panini
- 2 slices organic rosemary sourdough bread
- 1 tbsp ghee (such as Fourth And Heart)
- 3 tbsp homemade pesto
- Calabrian peppers (optional, omit if you don’t like spice)
- 1/2 avocado, thinly sliced
- 1 jar marinated roasted sweet red peppers
- 2–4 slices goat cheese
- 4 artichokes, quartered
- 6 slices organic deli chicken
- 1 cup arugula
- Fresh cracked black pepper, to taste
- Sea salt, to taste
Instructions
- Make the Basil Pesto: Combine extra virgin olive oil, walnuts and pine nuts, sea salt, freshly squeezed lemon juice, basil leaves, nutritional yeast, minced garlic, and ground pepper in a food processor. Pulse until smooth. Add 1-2 tablespoons water as needed to adjust consistency. Store any extra pesto in an airtight container in the refrigerator for up to 5 days or freeze in an ice cube tray for up to 3 months.
- Prepare the Bread: Spread ghee on the outside surfaces of both slices of rosemary sourdough bread to ensure a crispy, golden crust when toasted.
- Assemble the Panini: Spread 3 tablespoons of homemade pesto on the inside of one slice of bread. On the other slice, add Calabrian peppers if you enjoy spice. Layer thinly sliced avocado, marinated roasted sweet red peppers, organic deli chicken slices, cracked black pepper, goat cheese, arugula, quartered artichokes, and a sprinkle of sea salt evenly on the bread with the pesto.
- Grill the Panini: Close the sandwich and place it on a preheated panini press. Press down firmly and cook for about 5 minutes, or until the bread is golden and crispy and the cheese is melted.
- Alternative Cooking Method: If you don’t have a panini press, heat a skillet over medium heat. Place the assembled sandwich in the skillet, toast for about 2 minutes per side, pressing down with a spatula. Cover with a lid to help melt the cheese during toasting.
- Serve: Remove the panini from the press, slice if desired, and enjoy immediately, optionally pairing with a fresh side salad or chips for a complete meal.
Notes
- This pesto recipe makes extra; store in an airtight container in the refrigerator for up to 5 days or freeze in a silicone ice cube tray for up to 3 months.
- You can substitute the organic deli chicken with turkey or your preferred deli meat.
- Feel free to swap the goat cheese for another cheese variety or omit cheese for a dairy-free option.
- If you don’t like spice, omit the Calabrian peppers.
- Use a skillet and lid if you don’t have a panini press to achieve similar melty and crispy results.
- Pair the panini with a side salad and your favorite chips for a balanced meal.
Keywords: Loaded Chicken Pesto Panini, panini, sandwich, chicken sandwich, pesto recipe, grilled sandwich, healthy sandwich, high protein meal

